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WHITE PEONY (PAEONIA LACTIFLORA) ROOT EXTRACT BENEFITS

KEY BENEFITS OF WHITE PEONY

      • Promotes high quality sleep

      • Enhances mood

      • Supports brain function

ABOUT WHITE PEONY

Paeonia lactiflora, also known as white peony roots, is one of the most common herbs in Traditional Chinese Medicine. It is used for treating insomnia, promoting mental focus, and maintaining immunity.
 
As one of four herbs in TCM herbal formulas, this herb is part of Si Ni San, which supports sleep quality and reduces mental fatigue.
 
Researchers have shown that paeoniflorin [1] can affect adenosine signaling, which is critical to sleep homeostasis, in preclinical studies.
 
Aside from that, paeoniflorin has been found to support brain repair and protection processes (such as BDF-i, NGF, and BDNF), counter chronic stress, influence learning, and promote a healthy mood*.  

WHITE PEONY FULL BENEFITS

Stress

 

  • Supports healthy behavioural and physiological responses to stress [2–10]

  • Supports stress hormone levels [5,10,11]

 

Brain function

 

  • Supports learning and memory [8]

  • Supports sleep [12–14]

  • Supports adenosine signalling [12,13,15,16]

  • Supports acetylcholine signalling [17]

  • Supports serotonin levels [3,5,10]

  • Supports brain-derived neurotrophic factor (BDNF) [4,8,9,18]

  • Supports brain mitochondrial structure and function [19]

  • Supports hippocampal synaptic density [8,19]

  • Supports brain insulin signalling [19,20]

  • Modulates glycogen synthase kinase 3β (GSK3β) activity [20,21]

  • Supports cerebral blood flow [22]

  • Supports neuroprotective functions [15–17,19–25]

  • Supports brain mitochondrial function [19]

  • Supports brain autophagy [26]

 

Gut microbiota

 

  • Supports the composition of the gut microbiota [2]

WHITE PEONY (PAEONIA LACTIFLORA) ROOT EXTRACT CAN BE FOUND IN:

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REFERENCES

[1] X. Zhang, Y. Zhai, J. Yuan, Y. Hu, Sci. Rep. 9 (2019) 18469.

[2] J.-B. Yu, Z.-X. Zhao, R. Peng, L.-B. Pan, J. Fu, S.-R. Ma, P. Han, L. Cong, Z.-W. Zhang, L.-X. Sun, J.-D. Jiang, Y. Wang, Front. Pharmacol. 10 (2019) 268.

[3] F. Qiu, X. Zhong, Q. Mao, Z. Huang, Exp. Ther. Med. 5 (2013) 1113–1116.

[4] M.-Z. Hu, A.-R. Wang, Z.-Y. Zhao, X.-Y. Chen, Y.-B. Li, B. Liu, Neurol. Res. 41 (2019) 446–455.

[5] F.-M. Qiu, X.-M. Zhong, Q.-Q. Mao, Z. Huang, Neurosci. Lett. 541 (2013) 209–213.

[6] J. Li, S. Huang, W. Huang, W. Wang, G. Wen, L. Gao, X. Fu, M. Wang, W. Liang, H.Y. Kwan, X. Zhao, Z. Lv, Oncotarget 8 (2017) 8264–8282.

[7] S. Wang, X. Zhao, Z. Qiao, X. Jia, Y. Qi, Biomed. Pharmacother. 103 (2018) 248–252.

[8] S.-C. Liu, W.-Y. Hu, W.-Y. Zhang, L. Yang, Y. Li, Z.-C. Xiao, M. Zhang, Z.-Y. He, Psychopharmacology 236 (2019) 2823–2834.

[9] L.-B. Chen, F.-M. Qiu, X.-M. Zhong, C. Hong, Z. Huang, J. Integr. Neurosci. 18 (2019) 43–49.

[10] Z.-K. Qiu, J.-L. He, X. Liu, J. Zeng, W. Xiao, Q.-H. Fan, X.-M. Chai, W.-H. Ye, J.-S. Chen, Metab. Brain Dis. 33 (2018) 1175–1185.

[11] H. Huang, J. Zhao, L. Jiang, Y. Xie, Y. Xia, R. Lv, L. Dong, Int. J. Clin. Exp. Med. 8 (2015) 5103–5111.

[12] D. Yin, Y.-Y. Liu, T.-X. Wang, Z.-Z. Hu, W.-M. Qu, J.-F. Chen, N.-N. Cheng, Z.-L. Huang, Psychopharmacology 233 (2016) 281–293.

[13] C.-R. Chen, Y. Sun, Y.-J. Luo, X. Zhao, J.-F. Chen, Y. Yanagawa, W.-M. Qu, Z.-L. Huang, J. Pharmacol. Exp. Ther. 356 (2016) 64–73.

[14] Y. Li, P. Wu, Y. Ning, X. Yan, T. Zhu, C. Ma, A. Liu, J. Tradit. Chin. Med. 34 (2014) 184–187.

[15] D.-Z. Liu, K.-Q. Xie, X.-Q. Ji, Y. Ye, C.-L. Jiang, X.-Z. Zhu, Br. J. Pharmacol. 146 (2005) 604–611.

[16] H.-Q. Liu, W.-Y. Zhang, X.-T. Luo, Y. Ye, X.-Z. Zhu, Br. J. Pharmacol. 148 (2006) 314–325.

[17] C.-H. Ko, C.-P. Huang, Y.-W. Lin, C.-L. Hsieh, Iran. J. Basic Med. Sci. 21 (2018) 1174–1178.

[18] Y. Zhang, L.-L. Wang, Y. Wu, N. Wang, S.-M. Wang, B. Zhang, C.-G. Shi, S.-C. Zhang, Exp. Ther. Med. 12 (2016) 3729–3734.

[19] D. Wang, L. Liu, S. Li, C. Wang, Physiol. Behav. 191 (2018) 12–20.

[20] X. Sun, S. Li, L. Xu, H. Wang, Z. Ma, Q. Fu, R. Qu, S. Ma, Physiol. Behav. 174 (2017) 162–169.

[21] H.-R. Zhang, J.-H. Peng, X.-B. Cheng, B.-Z. Shi, M.-Y. Zhang, R.-X. Xu, Neurochem. Res. 40 (2015) 1583–1592.

[22] L.-G. Zhang, L.-J. Wang, Q.-Q. Shen, H.-F. Wang, Y. Zhang, C.-G. Shi, S.-C. Zhang, M.-Y. Zhang, Chin. J. Integr. Med. 23 (2017) 696–702.

[23] X.-Q. Luo, A. Li, X. Yang, X. Xiao, R. Hu, T.-W. Wang, X.-Y. Dou, D.-J. Yang, Z. Dong, Chin. Med. 13 (2018) 14.

[24] X. Gu, Z. Cai, M. Cai, K. Liu, D. Liu, Q. Zhang, J. Tan, Q. Ma, Mol. Med. Rep. 13 (2016) 2247–2252.

[25] J. Liu, D.-Z. Jin, L. Xiao, X.-Z. Zhu, Brain Res. 1089 (2006) 162–170.

[26] X.-S. Gu, F. Wang, C.-Y. Zhang, C.-J. Mao, J. Yang, Y.-P. Yang, S. Liu, L.-F. Hu, C.-F. Liu, Neurochem. Res. 41 (2016) 2923–2936.