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DHA BENEFITS

KEY BENEFITS OF DHA

    • Supports healthy vision
    • Supports brain health

ABOUT DHA

Among the omega-3 fatty acids (or n*3 fatty acids), docosahexaenoic acid (DHA) is one of the main three. The other two are alpha-linolenic acid (ALA) and eicosapentaenoic acid (EPA).

 

Among omega-3 fatty acids, DHA is the most abundant in the brain, where it occupies a central role in the membrane of neuronal cells and helps to facilitate cell signaling [1].

 

The retina also contains high levels of DHA, which contributes to healthy vision.

 

It is true that DHA can be produced in the body through the conversion of its precursor *-linolenic acid (ALA), but this only occurs in a limited amount. Diet is the main source of DHA.

 

The best food source of DHA (and EPA) is cold-water fish. DHA is mostly derived from the microalgae that fish consume. A vegan or vegetarian can increase their dietary intake of DHA without consuming fish or other animal products by taking DHA from algae, which eliminates the middleman.

DHA FULL BENEFITS

Neuronal structure

 

  • DHA is an omega-3 fatty acid found in cell membrane phospholipids [1]
  • DHA is the main structural component of the neuronal cell membrane [1]
  • Supports synaptic neuronal membrane fluidity [4]
  • Supports neuronal (dendritic) structure [5]

 

Brain function and cognition

 

  • Supports brain phospholipid levels [6]
  • Supports dopamine signaling [7]
  • Supports serotonin signaling [7]
  • Supports the HPA axis [7]
  • Supports neuronal choline uptake via the high-affinity choline uptake system [8]
  • Supports memory and learning [9–12]
  • Supports working memory [13]
  • Supports reaction time [13]
  • Supports cognitive health [9,11,12]
  • Supports neuroprotective functions [4,11,12,14]
  • Supports brain antioxidant defenses [11,12]

 

Mood

 

  • Supports a calm mood and healthy stress responses [15–18]
  • Supports positive affective responses [7]

 

Heart health

 

  • Supports healthy blood triglyceride levels [19,20]
  • Supports healthy blood cholesterol levels [19,20]

 

Longevity

 

  1. Supports AMP-Activated Protein Kinase (AMPK) activity [21,22]
  2. Supports SIRT-1 activity [21]
  3. Influences mTOR activity [22]
  4. Supports autophagy [22]

 

Complementary ingredients

 

  • Uridine in supporting memory, dendritic spine density, synaptic protein levels, and phospholipids in the brain [6,23–26]
  • Phosphatidylserine in supporting memory and cognitive health [27,28]

 

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REFERENCES

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[4]M. Hashimoto, S. Hossain, T. Shimada, O. Shido, Clin. Exp. Pharmacol. Physiol. 33 (2006) 934–939.
[5]F. Calon, G.P. Lim, F. Yang, T. Morihara, B. Teter, O. Ubeda, P. Rostaing, A. Triller, N. Salem Jr, K.H. Ashe, S.A. Frautschy, G.M. Cole, Neuron 43 (2004) 633–645.
[6]R.J. Wurtman, I.H. Ulus, M. Cansev, C.J. Watkins, L. Wang, G. Marzloff, Brain Res. 1088 (2006) 83–92.
[7]L.-H. Jiang, Q.-Y. Liang, Y. Shi, Eur. Rev. Med. Pharmacol. Sci. 16 (2012) 1765–1773.
[8]B.T. Hyman, A.A. Spector, J. Neurochem. 38 (1982) 650–656.
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[19]M.Y. Wei, T.A. Jacobson, Curr. Atheroscler. Rep. 13 (2011) 474–483.
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[21]B. Xue, Z. Yang, X. Wang, H. Shi, PLoS One 7 (2012) e45990.
[22]K. Jing, K.-S. Song, S. Shin, N. Kim, S. Jeong, H.-R. Oh, J.-H. Park, K.-S. Seo, J.-Y. Heo, J. Han, J.-I. Park, C. Han, T. Wu, G.-R. Kweon, S.-K. Park, W.-H. Yoon, B.-D. Hwang, K. Lim, Autophagy 7 (2011) 1348–1358.
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